Familial Parkinson's disease: a community‐based study
Identifieur interne : 001769 ( Main/Exploration ); précédent : 001768; suivant : 001770Familial Parkinson's disease: a community‐based study
Auteurs : M. Kurz ; G. Alves ; D. Aarsland [Norvège] ; J. P. LarsenSource :
- European Journal of Neurology [ 1351-5101 ] ; 2003-03.
English descriptors
- KwdEn :
Abstract
Genetic factors seem to be important in the pathogenesis of Parkinson's disease (PD). It is however, still controversial whether these factors also are reflected in a familial aggregation of PD. The aim of this study was to investigate the frequency of PD patients with a positive PD family history compared with two control groups. The included 245 PD patients were examined by neurologists and information was obtained through a semi‐structured interview. The patients and the control groups were examined for the frequency of PD and dementia in their families. The 245 patients with PD were included in this study. A positive PD‐family history could be obtained in 53 (21.6%) patients. The frequency was three‐ and four‐fold increased as compared with the control groups (P < 0.001). Age at onset of disease was not different among patients with and without PD in the family. The frequency of dementia did not differ in the family of individuals with and without PD (P > 0.1). As a conclusion our study of PD in a community based population supports previous reports of a three‐ to fourfold increased risk for PD in the families of patients with the disease. Our results indicate that the familial aggregation of the disease is independent of the age of the proband.
Url:
DOI: 10.1046/j.1468-1331.2003.00532.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Familial Parkinson's disease: a community‐based study</title><author><name sortKey="Kurz, M" sort="Kurz, M" uniqKey="Kurz M" first="M." last="Kurz">M. Kurz</name></author><author><name sortKey="Alves, G" sort="Alves, G" uniqKey="Alves G" first="G." last="Alves">G. Alves</name></author><author><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D." last="Aarsland">D. Aarsland</name></author><author><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J. P." last="Larsen">J. P. Larsen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DD2469E5C1451E3ED1A0D267C7B71F0F005ECD4F</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1046/j.1468-1331.2003.00532.x</idno><idno type="url">https://api.istex.fr/document/DD2469E5C1451E3ED1A0D267C7B71F0F005ECD4F/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001C98</idno><idno type="wicri:Area/Main/Curation">001A23</idno><idno type="wicri:Area/Main/Exploration">001769</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Familial Parkinson's disease: a community‐based study</title><author><name sortKey="Kurz, M" sort="Kurz, M" uniqKey="Kurz M" first="M." last="Kurz">M. Kurz</name><affiliation><wicri:noCountry code="subField">Norway; and</wicri:noCountry></affiliation></author><author><name sortKey="Alves, G" sort="Alves, G" uniqKey="Alves G" first="G." last="Alves">G. Alves</name><affiliation><wicri:noCountry code="subField">Norway; and</wicri:noCountry></affiliation></author><author><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D." last="Aarsland">D. Aarsland</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J. P." last="Larsen">J. P. Larsen</name><affiliation><wicri:noCountry code="subField">Norway; and</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Science Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2003-03">2003-03</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="159">159</biblScope><biblScope unit="page" to="163">163</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">DD2469E5C1451E3ED1A0D267C7B71F0F005ECD4F</idno><idno type="DOI">10.1046/j.1468-1331.2003.00532.x</idno><idno type="ArticleID">ENE532</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PD</term><term>Parkinson's disease</term><term>clementia</term><term>familial PD</term><term>hereditary PD</term><term>parkin</term><term>α‐synuclein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic factors seem to be important in the pathogenesis of Parkinson's disease (PD). It is however, still controversial whether these factors also are reflected in a familial aggregation of PD. The aim of this study was to investigate the frequency of PD patients with a positive PD family history compared with two control groups. The included 245 PD patients were examined by neurologists and information was obtained through a semi‐structured interview. The patients and the control groups were examined for the frequency of PD and dementia in their families. The 245 patients with PD were included in this study. A positive PD‐family history could be obtained in 53 (21.6%) patients. The frequency was three‐ and four‐fold increased as compared with the control groups (P < 0.001). Age at onset of disease was not different among patients with and without PD in the family. The frequency of dementia did not differ in the family of individuals with and without PD (P > 0.1). As a conclusion our study of PD in a community based population supports previous reports of a three‐ to fourfold increased risk for PD in the families of patients with the disease. Our results indicate that the familial aggregation of the disease is independent of the age of the proband.</div></front></TEI><affiliations><list><country><li>Norvège</li></country></list><tree><noCountry><name sortKey="Alves, G" sort="Alves, G" uniqKey="Alves G" first="G." last="Alves">G. Alves</name><name sortKey="Kurz, M" sort="Kurz, M" uniqKey="Kurz M" first="M." last="Kurz">M. Kurz</name><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J. P." last="Larsen">J. P. Larsen</name></noCountry><country name="Norvège"><noRegion><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D." last="Aarsland">D. Aarsland</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001769 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001769 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DD2469E5C1451E3ED1A0D267C7B71F0F005ECD4F
|texte= Familial Parkinson's disease: a community‐based study
}}
| This area was generated with Dilib version V0.6.23. |  |